Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation
نویسندگان
چکیده
منابع مشابه
P104: Obesity-Induced Neuroinflammation: Focus on Hypothalamic Inflammation
Obesity is a Health issue around the world. Obesity is not limited to body weight, generally associated with low grade inflammation and with a cluster of disorders generally referred to as "metabolic syndrome". Regarding obesity and relapse, long-term concentration was set on the hypothalamus. Most recently,obesity- Originated neuroinflammation has been shown to affect other brain str...
متن کاملUrea inhibits inducible nitric oxide synthase in macrophage cell line.
Macrophage dysfunction is considered an important contributory factor for increased propensity of infections in uremia. Because nitric oxide (NO) is believed to be an effector molecule of macrophage cytotoxicity, we propose that the dysfunction may be related to impaired NO synthesis. To verify this hypothesis, we evaluated macrophage NO synthesis in the presence of urea, a compound that accumu...
متن کاملUniversity of Groningen Inducible nitric oxide synthase in intestinal inflammation
Nitric oxide (NO) and reactive oxygen species (ROS) are important mediators in the pathogenesis of inflammatory bowel disease (IBD). NO in IBD can either be harmful or protective. NO can react with superoxide anions (O2) yielding the toxic oxidizing agent peroxynitrite (ONOO-). Peroxynitrite induces nitration of tyrosine residues (nitrotyrosine) leading to changes of protein structure and funct...
متن کاملBlastomyces dermatitidis yeast cells inhibit nitric oxide production by alveolar macrophage inducible nitric oxide synthase.
The ability of pathogens to evade host antimicrobial mechanisms is crucial to their virulence. The dimorphic fungal pathogen Blastomyces dermatitidis can infect immunocompetent patients, producing a primary pulmonary infection that can later disseminate to other organs. B. dermatitidis possesses a remarkable ability to resist killing by alveolar macrophages. To date, no mechanism to explain thi...
متن کاملNEL, Testosterone and Hypothalamic Nitric Oxide
OBJECTIVES: To determine the effect of testosterone administration to prepubertal (15 days old) and peripubertal rats (30 days old) on hypothalamic nitric oxide synthetase (NOS), and GnRH release. METHODS: Hypothalamic samples containing the anterior preoptic and medial basal areas (APO-MBH) were incubated for 30 minutes in 500 l of Earle’s medium with glucose (1 mg/ml) and bacitracin (20 mM). ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Reports
سال: 2018
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2018.09.070